Abstract: The muhifactor overlap analysis, based on GIS (hic Information System), is a new method of metallogenic prognosis, by which two nonferrous metallic deposits have been found within one target in Western Liaoning Province. In this paper, the authors introduce the result of the method applying in lead-zinc ore metallogenic prognosis in Liaohe group in Eastern Liaoning. The Liaohe group covers 7% land of the province, but about 43% of lead-zinc deposits occur in the stratum. Therefore Liaohe group has a great potential for lead-zinc ore prospecting. With the multifactor overlap analysis, 5 prospect areas and 11 targets are determined in Liaohe group. And more small or medium sized deposits are expected.