Abstract: The Panlong lead-zinc deposit, located in south section of the Pb-Zn-Cu-polymetallic mineralization belt in the west side of Dayaoshan Mountain, Guangxi Region, is of a middle scaled sedimentary-hot brine reformed type discovered in the last 10 years. The ore bodies are hosted mainly in the interlayer fracture zones of the Lower Devonian Shangkun dolostone, mostly in stratoid or lens shape, with multi-layered character and weak wallrock alteration. The metallic minerals in the ore occur as sulfides. Galena and sphalerite coexist with pyrite and barite. The Lower Devonian Shangkun dolostone, with well permeability and high lead and zinc abundance, is the favorable host horizon in the orefield. The ore body is related to the Early Yanshanian magmatic activity in time and space. Therefore, the deposit is obviously controlled by the lithology and structure, genetically related to sedimentation and magmatism.