Abstract: Nanfen-wanbao area is the concentrated zone for the polymetal deposits of molybdenum, copper, lead-zinc, etc. in Eastern Liaoning Province. Based on the study of regional metallogenic regularity, with MAPGIS software for data processing platform, 13 spatial ore-controlling factors, such as regional geology, geophysics and geochemistry, are extracted as evidence factors. The multiple metallogenic information is integrated by grid-setting to establish the evidence weighting model. By the way of posterior probability for inflexion, 13 perspective areas of Grade I, 10 of Grade Ⅱ and 7 of Grave Ⅲ are delineated. The result shows that 83% of deposits (occurrences) are located in the predicted perspective areas. It is worth noting that neither deposits nor occurrences have been found yet in 3 of the Grade I predicted perspective areas, which should be the key prospecting areas in the future.