Abstract: Due to the subduction of the Pacific plate in Mesozoic Era, severe volcanic-subvolcanic activities took place in the Daxinganling region. On the tectonic background of Mesozoic volcanic fault depression, amounts of Pb-Zn polymetal mineralization occur on the margin of the fault depression and the in the connecting belt between depression and uplift. The deposits are controlled by a series of volcanic-subvolcanic hypabyssal intrusive. The mineralization is formed nearly the same as or slightly later than the volcanic-subvolcanic activities. Six potential Pb-Zn metallogenic belts are recognized in the Daxinganling region, i.e. 1) Derbugan Pb-Zn (-Au-Ag) metallogenic belt; 2) Xiertala-Arshan Pb-Zn polymetal metallogenic belt; 3) Ulanhot-Lindong Pb-Zn polymetal metallogenic belt; 4) Linxi-Huanghetu Pb-Zn polymetal metallogenic belt; 5) Xilinhot-Chaobuleng Pb-Zn polymetal metallogenic belt; and 6) Xiaodonggou-Ongniud Pb-Zn polymetal metallogenic belt. The deposits can be assigned into three metallogenic types.