Abstract: The portable X-ray fluorescence spectrometer (XRF) of NITON XL3t 500 mode is applied in the Jinniuchang lead-zinc deposit in Huize, Yunnan Province for sample analysis condition test. The testing results of the XRF analyzer is compared with those in laboratory analysis. Comparisons between the two methods are also carried out in various humidity conditions to determine the best application conditions. The results show that the laboratory analysis and XRF analysis results are similar, although the humidity factor will reduce the element content. Therefore, the application of portable XRF analyzer is a convenient and effective method for sample testing.