Abstract: The Laoling area is an important lead-zinc-copper-gold metallogenic belt in Jilin Province. The Zhengcha leadzinc deposit is a typical skarn deposit in the belt, with metallogenic features of multi-stage and dual sources. Study on geology, geochemistry and geophysics shows that the ore materials are derived from the Mesozoic magma and the Paleoproterozoic marine volcanic-sedimentary source. Furthermore, the different mixing proportions between atmospheric water and magmatic water indicate that the "embryonic" of the deposit may have formed by Proterozoic era, during the volcanic eruption interval or the transition from volcanic eruption to marine sedimentation. The thermal effect of Mesozoic magmatic emplacement activated the original "embryonic", with further enrichment and mineralization. Based on the integrated analysis of regional metallogenic background and ore-controlling geological factors, a geological-geochemicalgeophysical criterion for ore prospecting is established.