Abstract: The Nayongzhi Pb-Zn deposit, situated in the northeast of Wuzhishan anticline, is a component of the Wuzhishan ore-concentrating zone. The orebodies occur in the dolostone of Cambrian Qingxudong formation, consisting of nine ore layers. The ores belong to carbonate rock type. The Ziyun-Yadu deep fault in the southwest and Anshun-Kaili deep fault in the southeast of the region are the prerequisites for the material source of the deposit. The secondary structures provide flow channels for ore fluid. The comprehensive Pb-Zn anomalies coincide to the regional structures, as well as the distribution of ore deposits (occurrences). The Nayongzhi Pb-Zn deposit is much comparable to the Mississippi Valley PbZn deposit. The geological characteristics of Nayongzhi Pb-Zn deposit show a great prospect of exploration in Wuzhishan region.