Abstract: The Nibo polymetallic deposit is situated in the intersection of Ailaoshan terrain, Honghe rift trough and Pingbian Xichou arc structure, where a few west-trending deep faults are derived, favorable for the copper-nickel metallogenesis. The Cu-Ni ore (mineralization) bodies occur in the grey purple migmatized garnet sillimanite biotite schist with migmatitic sillimanite biotite gneiss of the first member of Proterozoic Yaoshan group, with strong mylonitization. With study on the geological characteristics of the deposit, it is believed that the orebodies are closely related to the interlayer structures and superimposed structures. On the basis of analysis on previous exploration results, the follow-up prospecting targets are pointed out and the proper exploration methods are proposed.