Abstract: Based on the study of regional tectonic-sedimentary evolution of the Senegal Basin, with comprehensive analysis of reservoir-cap conditions, the basin evolution is devided into rift, transition and passive margin stages. The sedimentary strata are seperated into three parts:pre-salt sequence, salt sequence and post-salt sequence. The major petroleum system is the post-salt petroleum system, which is mainly distributs in the west of the basin. The key controlling factor to the petroleum is the Cretaceous source rock. Acorrding to the analysis of the resevior, the favourable prospective areas are put forward.