Abstract: Based on the analysis of the tectonic evolution and geological events in the Guizi area, Guangdong Province, it is confirmed that the crust in the area is characterized by multi-cycle evolution, with developing stages of geosyncline (Neoarchean-Early Paleozoic), paraplatform (Middle Devonian-Early Carboniferous) and continental margin mobile belt (Late Triassic-Holocene). With research of metallogenic conditions and mineral types, the metallogenesis in different epochs is analyzed. Three major mineralization periods in the studied area are determined. In the light of metallogenesis, oreforming times, distribution of deposits and the geological characteristics of deposits, the prospecting direction is discussed. Totally 11 ore prospective areas are delineated.