Abstract: The hydrothermal vein-type Pb-Zn-Ag deposits in the Derbugan metallogenic belt are characterized by intensive distribution, concentrated times of mineralization and similar metallogenic conditions. They have inherent relations in genesis. The Pb-Zn-Ag ore bodies occur mainly in the Middle-Late Jurassic volcanic rocks. The Early Cretaceous subvolcanic or intrusive rocks may be the essential sources of substance and power. The regional uplift-depression structures, volcanic edifices and volcanic-subvolcanic magmatism are the significant controlling factors. The NW-trending tensional-shearing fault system provides guide and host for ore-forming materials. The ore materials are mainly derived from the mantle. The ore-bearing hydrothermal fluid transmitted within the fracture system in the volcanic rocks, filled and replaced the surrounding rock metasomatism, making the precipitation and mineralization of ore-forming elements.