Abstract: Based on the discussion about the relationship between metallogenesis and geologic-tectonic evolution, combining with the geological and geochemical characteristics, it is pointed out that the Tianbaoshan Pb-Zn deposit and the Daliangzi Pb-Zn deposit were both formed in the tectonic-magmatic-hydrothermal process from Late Yanshanian to Himalayan stage, related to the intracontinental orogeny caused by the collision of Indian plate and Eurasia plate. The geochemical differences between the Tianbaoshan and Daliangzi Pb-Zn deposits are led by the differentiates of the geological environment in the area where the tectonic-magmatic-hydrothermal fluid existed and migrated, reflecting the different geological environment that formed in the long and complex geological evolution along the strike of the HuiliHuidong tectonic zone.