Abstract: Influenced by the Indo-Australian plate, Eurasian plate and Pacific plate, the Cenozoic tectonic stress field of Red River Plain was complex and diverse. Analysis on the variation of the Cenozoic tectonic stress field shows that the deformation in the Red River region is characterized by east-west sinistral compression in Early Cenozoic, while north-south dextral compression in Late Cenozoic, with an increasing trend of dextral slip compressive stresses in southeastern region. The variation of deformation in the Red River Plain provides conditions for the formation and development of the Red River delta and controls the modern north-south dynamic stress of the region.