Abstract: The authors evaluate the groundwater vulnerability in the Lower Liaohe River Plain with GIS-based DRASTIC method, analyze 7 major hydrogeological parameters that affect the vulnerability, and evaluate each factor respectively. Using merger analysis of spatial analysis function in GIS, the classification graphs for each single index are integrated to generate zone files and vulnerability map. The result shows that the areas with poor antifouling property are mainly distributed in the valleys of Lower Liaohe River Plain, with an area of 2993.51 km², accounting for 12.78% of the total. The assessment result is beneficial to the rational utilization of land and effective protection of groundwater resources.