Abstract: The Quanjianchong silver polymetallic deposit is located in the Huangmei-Huaining mineralization region within the Cu-Fe (polymetallic) metallogenic belt along the middle and lower reaches of Yangtze River. The diapiric invasion-extension-gliding structure formed by the Hongzhen granite intrusion into the core of Dongling anticline constitutes the basic structural framework of this region. The Ag-Pb-Zn polymetallic deposits that are related to tectonics and magmatic hydrothermal process are broadly developed in the area. With study on the geological characteristics and prospecting indicators of the silver polymetallic deposits in the orefield, it is concluded that the interfaces between the carbonaceous siliceous slates and carbonate rocks are advantageous metallogenic positions. Severe magmatism provides a large number of ore-bearing hydrothermal solutions for mineralization. The NE-trending detachment structures in the area serve as the ore-guiding and hosting structures. Special structural positions are important occurrences for silver polymetallic ore enrichment.