Abstract: The orebodies in Nanzhuang lead-zinc deposit, mostly concealed, are occurred in the quartz-keratophyre tuff of Huoshenmiao Formation, Erlangping Group, Lower Paleozoic. Through comprehensive analysis on the geological features of deposit, characteristics of trace and rare earth elements in ores, and isotopic geochemistry, it is found that the deposit is characterized by hydrothermal deposition and mixing of seawater sulfur and mantle-derived sulfur, with the ore-forming materials mainly derived from the upper mantle, mixed with the characteristics of orogenic belt and upper crust. It is basically determined that the deposit belongs to submarine volcanic exhalation massive sulfide type reformed by weak metamorphism, and the strata-lithology-alteration-geophysical prospecting indicators are established based on the above.