Abstract: The Beiershijiazi Cu-Au deposit in Liaoning Province is located in Chaoyang-Chifeng gold metallogenic belt on the northern margin of North China Platform, where quite a few Cu-Au ore/mineralized occurrences of altered rock type are controlled by NW- and NE-trending faults. Three types of soil geochemical anomalies were delineated by soil geochemical survey, including 4 of I-type, 8 of II-type and 16 of III-type. Geophysical exploration is carried out in the areas with well geochemical anomalies, among which the high resistivity area of geophysical exploration coincides with the I-type anomaly area of geochemical exploration, and 3 anomaly areas and 4 deep targets are delineated by IP intermediate gradient and IP sounding. Based on the geological, geophysical and geochemical characteristics of the area, it is considered that the development of hydrothermal alteration mineral assemblages such as silicification, pyritization and chalcopyritization are key prospecting indicators of petromineralogy. The contact zone of Paleoproterozoic Baoyintu Group strata and granitic gneiss, NW- and NE-trending tectono-altered fracture zones, and high-sulfide areas are important prospecting targets.