Abstract: Based on the investigation, sampling and drilling, combined with previous data, the SPSS and groundwater pollution analysis softwares are used to analyze the regional geological conditions, groundwater quality, drinking water quality and farmland irrigation water quality characteristics in Oroqen Qi. It is considered that the groundwater iron and manganese contents in Oroqen Qi is controlled by the high background values of soil iron and manganese in Northeast China, and the generally high contents result in the increase of groundwater chroma and turbidity. Influenced by human activities, the mass concentrations of As, SO₄^2-, NH₄⁺ and NO₂^- in groundwater of different areas vary greatly. According to the agricultural and industrial water quality requirements and certain level of human health risk, high iron, manganese, chroma, turbidity, pH value, sulfate radical and fluoride ion content result in the groundwater in part of well locations reaching the Class Ⅳ water standard, basically suitable for agriculture and some industrial water, and used for drinking water after proper treatment. By fully understanding the variation rule of groundwater quality in the region, it is suggested that the pollution of groundwater caused by human factors be reduced as far as possible.