Abstract: Based on the determination of oil-source fault and analysis of its controlling factors for advantageous pathways of hydrocarbon migration, the 3D seismic, well logging and mud logging data are used to study the advantage pathways on the parts of oil-source fault activity, internal lithology and hydrocarbon potential field, and then to comprehensively predict the advantage pathway of oil-source fault. The comprehensive evaluation parameters of advantageous pathways of hydrocarbon migration by oil-source fault are calculated by weighted assignment to determine the favorable range of hydrocarbon accumulation near the oil-source fault. The method is used to predict the advantageous pathways of hydrocarbon migration by F3 oil-source fault in Daliuquan area of Langgu Sag in Mid-Hebei Depression, Bohai Bay Basin. The results show that there are 11 advantageous pathways developed in F3 fault, including 3 of activity, 2 of internal lithology and 6 of section hydrocarbon potential. The favorable hydrocarbon accumulation area near the F3 fault is restricted by the comprehensive evaluation parameter greater than 1.65, which is consistent with the proven hydrocarbon distribution in the study area, indicating that the method is feasible for the prediction of advantageous pathways for hydrocarbon migration in oil-source fault, and helpful for favorable oil-gas target searching.