Abstract: The Central Jilin-Yanbian metallogenic belt, one of the 12 important nickel mineralization belts in China, containing 13 nickel deposits(occurrences), with nickel reserves of more than 280 000 tons, is an important nickel resource base in China. There are intense multistage tectonomagmatic activities in the metallogenic belt, especially a series of ultramafic-mafic rock groups and related copper-nickel sulfide deposits were formed in the Indosinian post-orogenic extensional background. Through study on the two typical nickel deposits in Hongqiling and Changren, the paper sorts out the geological and metallogenic characteristics of nickel deposits, summarizes the spatiotemporal distribution regularity, and extracts the prospecting indicators. Based on the regional geological characteristics and gravity, aeromagnetic anomalies, the prospecting potential of copper-nickel sulfide deposits in Central Jilin-Yanbian metallogenic belt is analyzed, and the prospecting direction of nickel deposits is discussed to provide scientific basis for the further nickel prospecting deployment in the metallogenic belt.