Abstract: Yangkang area is located in the Hala Lake-Longmen Caledonian W-Au-Cu-Co metallogenic subbelt of Caledonian W-Sn-Au-Cu metallogenic belt on the southern side of Qilian Mountains, with dozens of metal deposits (occurrences) found in the metallogenic belt, which has a good polymetallic exploration prospect. A total of 5 polymetallic mineral occurrences or mineralization spots have been found in the area. Through the 1:50 000 stream sediment survey, the primary data of 20 elements in the area are analyzed, among which the abundances of 10 elements such as Au, As, Sb, W, Pb and Zn are higher than the average of the region, especially highly enriched in the metamorphic sandstone of Silurian Balonggar Formation. The statistical analysis of stream sediments shows that the enrichment coefficient (K) of Au is 2.14, with great variation coefficients of Au, Pb and W. The samples are classified into 4 subclusters by R-type cluster analysis, i.e. Ⅱ-1 of As-Sb-Mo, Ⅱ-2 of Bi-Sn-Rb-U, Ⅱ-3 of Ba and Ⅱ-4 of Ag-Pb. From the 48 delineated comprehensive anomalies, 2 of Class A and 2 of Class B anomalies with good representativeness and exploration prospects are selected for emphasis discussion. According to the element distribution, element correlation and comprehensive anomaly characteristics, combined with the regional metallogenic background, 3 metallogenic prospect areas are defined, namely the second-order Sereduolong Au-W metallogenic prospect area, second-order Duoergai Pb-Zn metallogenic prospect area and third-order Lamulong W-Cu-Au metallogenic prospect area.