Abstract: The eastern Liaoning-southern Jilin area is an important boron mineral resource base in China, with numerous large and super-large boron deposits. The medium-sized Ertaizi boron deposit, located in the central part of eastern Liaoning-southern Jilin metallogenic belt, had been explored and developed early before it was closed. To evaluate the boron resource potential in the periphery of Ertaizi boron deposit, the paper studies the regional geophysical and geochemical data. The results reveal that both the regional geochemical anomaly and gravity-magnetic anomaly show a dislocation in the middle of the study area, suggesting the existence of F1 fault. According to the geological data, on the northeast side of F1 fault, there is a complex fold composed of a syncline and an anticline, with a NE-trending fold axis. The Ertaizi boron deposit is situated at the south end of eastern wing of the anticline, within the aeromagnetic anomaly and on the edge of residual gravity anomaly. Areas where gravity-magnetic anomaly coincide or where magnetic anomaly occur within gravity anomaly zones are favorable targets for boron prospecting. A few areas along the eastern wing of the anticline to the north exhibit characteristics similar to those of Ertaizi boron deposit, particularly at the hinge of northern fold where gravity-magnetic anomalies overlap with geochemical anomalies, making these areas highly prospective for boron exploration.