Abstract: The lead-zinc resources are abundant in the world and distributed in more than 50 countries. By collecting the data and information of lead-zinc deposits at home and abroad, based on the systematic review of the data of 1035 Pb-Zn deposits and 3319 occurrences/mineralized spots in the world, the paper comparatively studies the resources and reserves of global Pb-Zn deposits from different data sources, comprehensively analyzes the resources distribution and spatiotemporal distribution regularity of mineralization for the three major genetic types including sedimentary exhalative (SEDEX), volcanic massive sulfide (VMS) and Mississippi Valley-type (MVT), and summarizes the deposit reserves, resources, grades, metallogenic types and characteristics of the worldwide large Pb-Zn deposits, to provide reference for the comprehensive research of global Pb-Zn deposits.