Abstract: The Moshishan volcanic basin, located in the middle of the Binxian-Yichun-Gansin volcanic-type uranium-molybdenum metallogenic belt, is a small-medium sized Cretaceous volcanic basin. A uranium mineralization anomaly is newly discovered with one anomaly belt and two high anomaly points in Gunzigou area in the north of the basin. Based on the geological and mineralization characteristics, combined with regional tectonic setting, stratigraphy, intrusive rocks and structures, by analysis on the metallogenic condition and ore-controlling factors, it is thought that the host rock occurred in the anomaly area is cataclastic rhyolite of Ningyuancun formation, Early Cretaceous, controlled by the NNE-trending fault. The main alteration types are silicification and hematitization with obvious zonation. The comparative analysis with regional uranium-productive volcanic basins shows that Moshishan volcanic basin has greater mineralization prospects. According to the uranium mineralization characteristics in Guizigou area, further uranium prospecting in volcanic basins can be carried out.