Abstract: Based on the theory of metallogenic series, the deposits in Guangdong Province are studied by combining the mineragenetic epoch, geotectonic environment, significant mineralization and deposit associations. The deposits are divided into 21 series with 37 subseries. The metallogenic lineage is established according to the evolutionary relationship between metallogenic cycles and series. The study shows that the metallogenic series are obviously uneven in spatial-temporal distribution but with sequence and cyclicity over time. Finally, the existing problems in study are discussed and suggestions for further study are put forward.