Abstract: Through studying the uranium source conditions, Mesozoic tectonic evolution and Cretaceous sedimentary formation of the provenance area in northeast Songliao Basin, combined with the seismic well-tie section data of petroleum sectors, the paper analyzes the metallogenic conditions of sandstone uranium deposits comprehensively. It is believed that the uranium-rich granite body in the basin margin provides abundant uranium sources and the denudation window formed by the inversion structure in Late Mesozoic serves as the channel for infiltration and seepage of uranium-containing and oxygenated water. The results show that Suiling area in the northeast of Songliao Basin is the most favorable prospecting site for sandstone uranium deposits, with the Upper Cretaceous Quantou Formation and the shallow part of Yaojia Formation as the main target layers, focusing on the type of interlayer oxidation zone.