Abstract: Guliku gold (-silver) deposit is located at the connection of Dayangshu volcanic basin and Luomahu intermediate uplift. Besed on the stable isotope composition study, a mineralization model for Gulilu Au (-Ag) deposit is proposed, i.e.an adular-sericite type of epithermal gold (-silver) deposit with horizontally zoned Au-Ag ore bodies occurring in the limb of a paleo-volcanic dome on the margin of a Mesozoic continental volcanic basin.The mineralization is in two stages.The temperature of the early stage is between 240℃ and 280℃,while that of the late stage is from 185℃ to 235℃.The isotopic composition (δD_H2O-76‰ to-94‰,δ¹⁸O-6.58‰ to-14.11‰) suggests that the minerlizing solution is derived from mainly meteoric water. The S and Pb isotopic study shows that the "hydrothermal sulfur" is derived from volcanic rocks and the "hydrothermal lead" is from the basement and associated granitoids.