Abstract: Zhenan-Xunyang area of Shaanxi Province is one of the main metal mineral sources in Southern Qinling Mountains. The major metal resources are Hg-Sb, Pb-Zn and Au deposits, which are different but correlative in source materials, physical-chemical conditions and the characters of mineralizing fluid. By the study on the isotopes and fluid inclusions in the area, with analysis of their geodynamics background, it shows that the source material of Pb-Zn deposits and Au deposits are both related to submarine exhalation, and the mineralization backgrounds of Hg-Sb deposits and Au deposits are the same. The deposits are related to each other, forming a genetic system from Late Paleozoic to Early Mesozoic eras in Zhenan-Xunyang area.