Abstract: The southwest part of Songliao Basin is developed on the Xingan-Mongolian-Ji-Hei Hercynian folded belt, connected to the Mongolian-Daxinganling Hercynian folded belt on the northwest and bounded by the North China platform on the southeast. Applying criteria of geologic prognosis and evaluation for hydrogenic uranium deposit, we studied on the Upper Tertiary stratigraphy, lithofacies, lithology, paleoclimate, geochemical environment, hydrogeologic conditions and the interlayer oxidation zone of the southwestern Songliao Basin. The result shows that the Upper Tertiary interlayer oxidation zone has a positive metallogenic condition for sandstone type of uranium deposits. Therefore the potential areas for uranium prospecting of Shebotu and Kailu are predicted.