Abstract: The south section of Western Tianshan Mt. is tectonically situated in the south margin mobile belt of Ili subplate and the marginal mobile belt of Tarim plate. The regional E-W trending major fault controls the distribution of strata, magmatic rocks and geochemical anomalies. Silurian-Devonian sediments of carbonaceous detrital rocks and carbonate rocks are dominant in the area. The main metallogenic elements and associated elements are concentrated in Silurian, Devonian and Carboniferous strata, which are, thus, the most potential horizons for prospecting. The Silurian system is rich in Au, As, Sb, Sn, Zn, Cr, Ni, Co and Ti, with uneven distribution and various assemblages. The microelements tend to enrich and mineralize locally. The single element anomalies of Au, As, Sb, Hg or Cu and multi-element anomalies are obvious in the geochemical map. The geochemical background of Devonian system is generally high. The elements are distributed unevenly, with complex assemblages. Au, As, Sb and Hg are rich. Multi-element anomalies are shown. Based on the distribution of element anomalies, the types of assemblages and the anomaly-controlling factors, the studied area is subdivided into 4 anomalous zones, including 9 subzones.