Abstract: In Maoling gold deposit, Huangjayingzi gold deposit, Jinchanggou gold deposit and Waizi gold deposit in southern Liaoning, the ore lead and K-feldspar lead of Mesozoic biotite adamellite porphyritic-like are two-stage anomalous lead. The lead isotope compositions of both show identical value approximately.The lead isotope compositions from Maoling gold deposit is approximately consistent with that of the metamorphic rocks of Proterozoic Gaixian group, This indicates that the mineralization interial was derived from Mesozoic porphyritic-like biotite adamellite and the metamorphic rocks of Gaixian group.A ccording to studing result of hydrogen and oxygen isotope compositions, the mineralization hydrothermal solution of gold deposits was derived from mainly the hydrothermal solution of granite magma, and mixed with a little meteoric water.